Bioinformatics analyses reveal age-specific neuroimmune modulation as a target for treatment of high ethanol drinking.

@article{Agrawal2014BioinformaticsAR,
  title={Bioinformatics analyses reveal age-specific neuroimmune modulation as a target for treatment of high ethanol drinking.},
  author={Rajiv G. Agrawal and Julie Ann Owen and Patricia S. Levin and Aveline Hewetson and Ari E. Berman and Scott R. Franklin and Ryan J Hogue and Yukun Chen and Chris Walz and Benjamin D. Colvard and Jonathan Nguyen and Oscar Reynaldo Talavera Vel{\'a}squez and Yazan M Al-Hasan and Yuri Alexeevich Blednov and Anna-Kate Fowler and Peter J. Syapin and Susan E. Bergeson},
  journal={Alcoholism, clinical and experimental research},
  year={2014},
  volume={38 2},
  pages={
          428-37
        }
}
BACKGROUND Use of in silico bioinformatics analyses has led to important leads in the complex nature of alcoholism at the genomic, epigenomic, and proteomic level, but has not previously been successfully translated to the development of effective pharmacotherapies. In this study, a bioinformatics approach led to the discovery of neuroimmune pathways as an age-specific druggable target. Minocycline, a neuroimmune modulator, reduced high ethanol (EtOH) drinking in adult, but not adolescent, mice… CONTINUE READING
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Effective Reduction in High Ethanol Drinking by Semisynthetic Tetracycline Derivatives.

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  • 2016
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