Bioinformatics Meets Proteomics - Bridging the Gap between Massspectrometry Data Analysis and Cell Biology

@article{Kearney2003BioinformaticsMP,
  title={Bioinformatics Meets Proteomics - Bridging the Gap between Massspectrometry Data Analysis and Cell Biology},
  author={P. Kearney and Pierre Thibault},
  journal={Journal of bioinformatics and computational biology},
  year={2003},
  volume={1 1},
  pages={
          183-200
        }
}
Proteomics research programs typically comprise the identification of protein content of any given cell, their isoforms, splice variants, post-translational modifications, interacting partners and higher-order complexes under different conditions. These studies present significant analytical challenges owing to the high proteome complexity and the low abundance of the corresponding proteins, which often requires highly sensitive and resolving techniques. Mass spectrometry plays an important… CONTINUE READING
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