Bioinformatic approach to identify chaperone pathway relationship from large-scale interaction networks.

@article{Gong2011BioinformaticAT,
  title={Bioinformatic approach to identify chaperone pathway relationship from large-scale interaction networks.},
  author={Yunchen Gong and Zhaolei Zhang and Walid A. Houry},
  journal={Methods in molecular biology},
  year={2011},
  volume={787},
  pages={
          189-203
        }
}
We describe a computational protocol to identify functional modules and pathway relationship of chaperones based on physical interaction data derived from high-throughput proteomic experiments. The protocol first identifies interacting proteins shared by the different chaperone systems to organize the chaperones into functional modules. The chaperone functional modules represent groups of chaperones that are involved in mediating the folding of the shared interacting proteins. Either the… CONTINUE READING
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