Bioinformatic approach to identify chaperone pathway relationship from large-scale interaction networks.

  title={Bioinformatic approach to identify chaperone pathway relationship from large-scale interaction networks.},
  author={Yunchen Gong and Zhaolei Zhang and Walid A. Houry},
  journal={Methods in molecular biology},
We describe a computational protocol to identify functional modules and pathway relationship of chaperones based on physical interaction data derived from high-throughput proteomic experiments. The protocol first identifies interacting proteins shared by the different chaperone systems to organize the chaperones into functional modules. The chaperone functional modules represent groups of chaperones that are involved in mediating the folding of the shared interacting proteins. Either the… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper


Publications citing this paper.


Publications referenced by this paper.
Showing 1-10 of 16 references

The BioGRID Interaction Database: 2008 update

Nucleic Acids Research • 2008
View 7 Excerpts
Highly Influenced

Converging concepts of protein folding in vitro and in vivo

Nature Structural &Molecular Biology • 2009
View 4 Excerpts
Highly Influenced

KEGG for linking genomes to life and the environment

Nucleic Acids Research • 2008
View 3 Excerpts
Highly Influenced

Hsp104 and ClpB: protein disaggregating machines.

Trends in biochemical sciences • 2009
View 3 Excerpts