Bioinformatic analysis of a PLP-dependent enzyme superfamily suitable for biocatalytic applications.

  title={Bioinformatic analysis of a PLP-dependent enzyme superfamily suitable for biocatalytic applications.},
  author={Fabian Steffen-Munsberg and Clare Vickers and Hannes Kohls and Henrik Land and Hendrik Mallin and Alberto Nobili and Lilly Skalden and Tom van den Bergh and Henk-Jan Joosten and Per Berglund and Matthias H{\"o}hne and Uwe T Bornscheuer},
  journal={Biotechnology advances},
  volume={33 5},
In this review we analyse structure/sequence-function relationships for the superfamily of PLP-dependent enzymes with special emphasis on class III transaminases. Amine transaminases are highly important for applications in biocatalysis in the synthesis of chiral amines. In addition, other enzyme activities such as racemases or decarboxylases are also discussed. The substrate scope and the ability to accept chemically different types of substrates are shown to be reflected in conserved patterns… CONTINUE READING


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