Bioinformatic Approaches for Predicting substrates of Proteases

@article{Song2011BioinformaticAF,
  title={Bioinformatic Approaches for Predicting substrates of Proteases},
  author={Jiangning Song and Hao Tan and Sarah E. Boyd and Hongbin Shen and Khalid Mahmood and Geoffrey I. Webb and Tatsuya Akutsu and James C. Whisstock and Robert N. Pike},
  journal={Journal of bioinformatics and computational biology},
  year={2011},
  volume={9 1},
  pages={
          149-78
        }
}
Proteases have central roles in "life and death" processes due to their important ability to catalytically hydrolyze protein substrates, usually altering the function and/or activity of the target in the process. Knowledge of the substrate specificity of a protease should, in theory, dramatically improve the ability to predict target protein substrates. However, experimental identification and characterization of protease substrates is often difficult and time-consuming. Thus solving the… 

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