Bioimaging of metals by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS).

@article{Becker2010BioimagingOM,
  title={Bioimaging of metals by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS).},
  author={Johanna Sabine Becker and Miroslav V Zoriy and Andreas Matusch and Bei Lei Wu and Dagmar Salber and Christoph Palm and Julia Susanne Becker},
  journal={Mass spectrometry reviews},
  year={2010},
  volume={29 1},
  pages={
          156-75
        }
}
The distribution analysis of (essential, beneficial, or toxic) metals (e.g., Cu, Fe, Zn, Pb, and others), metalloids, and non-metals in biological tissues is of key interest in life science. Over the past few years, the development and application of several imaging mass spectrometric techniques has been rapidly growing in biology and medicine. Especially, in brain research metalloproteins are in the focus of targeted therapy approaches of neurodegenerative diseases such as Alzheimer's and… 

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References

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Imaging Mass Spectrometry in Biological Tissues by Laser Ablation Inductively Coupled Plasma Mass Spectrometry
TLDR
LA-ICP-MS was used to produce images of detailed regionally-specific element distribution in 20 μm thin sections of different parts of the human brain, resulting in quantitative determination of copper, zinc, lead and uranium distribution in thin slices of human brain samples.
Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) in elemental imaging of biological tissues and in proteomics
Of all the inorganic mass spectrometric techniques, laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) plays a key role as a powerful and sensitive microanalytical technique,
Imaging of essential and toxic elements in biological tissues by LA-ICP-MS
Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) using double-focusing sector field (LA-ICP-SFMS) or quadrupole-based mass spectrometers (LA-ICP-QMS) was employed as powerful
Imaging of uranium on rat brain sections using laser ablation inductively coupled plasma mass spectrometry: a new tool for the study of critical substructures affined to heavy metals in tissues.
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IMS using laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) with a spatial resolution in the 100 microm range was developed and employed to study heavy metal distribution in brain tissues for toxicological screening.
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