Biogenic Amines in Rett Syndrome: The Usual Suspects

@article{Roux2010BiogenicAI,
  title={Biogenic Amines in Rett Syndrome: The Usual Suspects},
  author={J. Roux and L. Villard},
  journal={Behavior Genetics},
  year={2010},
  volume={40},
  pages={59-75}
}
  • J. Roux, L. Villard
  • Published 2010
  • Biology, Medicine
  • Behavior Genetics
  • Rett syndrome (RTT) is a severe postnatal neurological disorder caused by mutations in the methyl-CpG binding protein 2 (MECP2) gene. In affected children, most biological parameters, including brain structure, are normal (although acquired microcephaly is usually present). However, in recent years, a deficit in bioaminergic metabolism has been identified at the cellular and molecular levels, in more than 200 patients. Recently available transgenic mouse strains with a defective Mecp2 gene also… CONTINUE READING
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