Biogenesis pathways of piRNAs loaded onto AGO3 in the Drosophila testis.

@article{Nagao2010BiogenesisPO,
  title={Biogenesis pathways of piRNAs loaded onto AGO3 in the Drosophila testis.},
  author={Akihiro Nagao and Toutai Mituyama and Haidong Huang and Dahua Chen and Mikiko C Siomi and Haruhiko Siomi},
  journal={RNA},
  year={2010},
  volume={16 12},
  pages={2503-15}
}
PIWI-interacting RNAs (piRNAs) silence transposable elements in animal germ cells. In Drosophila ovaries, piRNAs are produced by two distinct pathways: the "ping-pong" amplification cycle that operates in germ cells and a ping-pong-independent pathway termed the primary pathway that mainly operates in somatic cells. AGO3, one of three PIWI proteins in flies… CONTINUE READING