Biogenesis of the Saccharomyces cerevisiae pheromone a-factor, from yeast mating to human disease.

@article{Michaelis2012BiogenesisOT,
  title={Biogenesis of the Saccharomyces cerevisiae pheromone a-factor, from yeast mating to human disease.},
  author={Susan Michaelis and Jemima Barrowman},
  journal={Microbiology and molecular biology reviews : MMBR},
  year={2012},
  volume={76 3},
  pages={626-51}
}
The mating pheromone a-factor secreted by Saccharomyces cerevisiae is a farnesylated and carboxylmethylated peptide and is unusually hydrophobic compared to other extracellular signaling molecules. Mature a-factor is derived from a precursor with a C-terminal CAAX motif that directs a series of posttranslational reactions, including prenylation, endoproteolysis, and carboxylmethylation. Historically, a-factor has served as a valuable model for the discovery and functional analysis of CAAX… CONTINUE READING
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