Biogenesis of reactive sulfur species for signaling by hydrogen sulfide oxidation pathways.

@article{Mishanina2015BiogenesisOR,
  title={Biogenesis of reactive sulfur species for signaling by hydrogen sulfide oxidation pathways.},
  author={Tatiana Vladimirovna Mishanina and Marouane Libiad and Ruma Banerjee},
  journal={Nature chemical biology},
  year={2015},
  volume={11 7},
  pages={
          457-64
        }
}
The chemical species involved in H2S signaling remain elusive despite the profound and pleiotropic physiological effects elicited by this molecule. The dominant candidate mechanism for sulfide signaling is persulfidation of target proteins. However, the relatively poor reactivity of H2S toward oxidized thiols, such as disulfides, the low concentration of disulfides in the reducing milieu of the cell and the low steady-state concentration of H2S raise questions about the plausibility of… CONTINUE READING
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Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling.

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