Biogenesis of Hyoscyamine

@article{Leete1954BiogenesisOH,
  title={Biogenesis of Hyoscyamine},
  author={E. Leete and L. Marion and I. D. Spenser},
  journal={Nature},
  year={1954},
  volume={174},
  pages={650-651}
}
THE biogenetic origin of the tropane bases has recently been the subject of some discussion1,2, Mortimer1 suggesting that the tropane skeleton may be derived from the breakdown products of tryptophan metabolism. This novel idea is contrary to the accepted hypothesis that a base such as tropine is produced in vivo by reactions analogous to the in vitro synthesis3 of tropinone from succindialdehyde, methylamine and acetone. The succindialdehyde is considered to be a metabolite of ornithine, and… Expand
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THE isolation of both hyoscine and nicotine from a genotype of Duboisia myoporoides1 suggests the possibility of a close biosynthetic relation between these bases, and is consequently of interest inExpand
Biogenesis of Alkaloids of Solanaceæ
THIRTY-SIX years ago1 I directed attention to the structural relations between hygrine, cuskhygrine, tropine and other similar bases, and drew the conclusion that the units concerned in theExpand
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Action of Ninhydrin on Keratin
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The basic side-chains of keratin must play a fundamental part in the cross-linking reaction, since no strengthening is obtained with completely deaminated fibres, and the extent of reaction is reduced when the lysine side- chains are blocked by means of 1-fluoro-2 : 4-dinitrobenzene or nitroso-benzenes. Expand