Biogenesis of Hyoscyamine

@article{Leete1954BiogenesisOH,
  title={Biogenesis of Hyoscyamine},
  author={E. Leete and L. Marion and I. D. Spenser},
  journal={Nature},
  year={1954},
  volume={174},
  pages={650-651}
}
THE biogenetic origin of the tropane bases has recently been the subject of some discussion1,2, Mortimer1 suggesting that the tropane skeleton may be derived from the breakdown products of tryptophan metabolism. This novel idea is contrary to the accepted hypothesis that a base such as tropine is produced in vivo by reactions analogous to the in vitro synthesis3 of tropinone from succindialdehyde, methylamine and acetone. The succindialdehyde is considered to be a metabolite of ornithine, and… Expand
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Methods Citations
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Tropane and Related Alkaloids
Chapter 5 The Tropane Alkaloids
Biogenetic-type syntheses of natural products.
Synthesis of tropine-labeled atropine. I. Micro methods for the synthesis of tropine and for its esterification with tropic acid.
Synthesis of tropine-labeled atropine. IV. Labeling of the 2, 3, and 4 positions of atropine from citric-14-C acid.
Tropinone synthesis via an atypical polyketide synthase and P450-mediated cyclization
Recent development in the synthesis and stereochemistry of tropane alkaloids
Tropane alkaloids biosynthesis involves an unusual type III polyketide synthase and non-enzymatic condensation
Chapter 1 Alkaloids in the Plant
Atropine [(±)-Hyoscyamine] and Cocaine (Ornithine-Derived Alkaloids)
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