Biogenesis and function of fibrillin assemblies

@article{Ramrez2009BiogenesisAF,
  title={Biogenesis and function of fibrillin assemblies},
  author={F. J. Estrada Ram{\'i}rez and Lynn Yasuko Sakai},
  journal={Cell and Tissue Research},
  year={2009},
  volume={339},
  pages={71-82}
}
Fibrillin-1 and fibrillin-2 are large cysteine-rich glycoproteins that serve two key physiological functions: as supporting structures that impart tissue integrity and as regulators of signaling events that instruct cell performance. The structural role of fibrillins is exerted through the temporal and hierarchical assembly of microfibrils and elastic fibers, whereas the instructive role reflects the ability of fibrillins to sequester transforming growth factor β (TGFβ) and bone morphogenetic… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 115 REFERENCES

Extracellular microfibrils in development and disease

  • Cellular and Molecular Life Sciences
  • 2007
VIEW 13 EXCERPTS
HIGHLY INFLUENTIAL

Fibrillin-1 regulates the bioavailability of TGFβ1

  • The Journal of cell biology
  • 2007
VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL

Effects of fibrillin-1 degradation on microfibril ultrastructure.

  • The Journal of biological chemistry
  • 2006
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Fibrillins 1 and 2 perform partially overlapping functions during aortic development.

  • The Journal of biological chemistry
  • 2006
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Vascular extracellular matrix and aortic development.

  • Current topics in developmental biology
  • 2004
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

Regulation of limb patterning by extracellular microfibrils

  • The Journal of cell biology
  • 2001
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL