Biogenesis and cargo selectivity of autophagosomes.

  title={Biogenesis and cargo selectivity of autophagosomes.},
  author={Hilla Weidberg and Elena Shvets and Zvulun Elazar},
  journal={Annual review of biochemistry},
Autophagy is a major catabolic pathway in eukaryotes, which is required for the lysosomal/vacuolar degradation of cytoplasmic proteins and organelles. Interest in the autophagy pathway has recently gained momentum largely owing to identification of multiple autophagy-related genes and recognition of its involvement in various physiological conditions. Here we review current knowledge of the molecular mechanisms regulating autophagy in mammals and yeast, specifically the biogenesis of… CONTINUE READING
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