Biofunctionalized gold nanoparticles for colorimetric sensing of botulinum neurotoxin A light chain.

@article{Liu2014BiofunctionalizedGN,
  title={Biofunctionalized gold nanoparticles for colorimetric sensing of botulinum neurotoxin A light chain.},
  author={Xiaohu Liu and Yi Wang and Peng Chen and Yusong Wang and Jinling Zhang and Daniel Aili and Bo Liedberg},
  journal={Analytical chemistry},
  year={2014},
  volume={86 5},
  pages={
          2345-52
        }
}
Botulinum neurotoxin is considered as one of the most toxic food-borne substances and is a potential bioweapon accessible to terrorists. The development of an accurate, convenient, and rapid assay for botulinum neurotoxins is therefore highly desirable for addressing biosafety concerns. Herein, novel biotinylated peptide substrates designed to mimic synaptosomal-associated protein 25 (SNAP-25) are utilized in gold nanoparticle-based assays for colorimetric detection of botulinum neurotoxin… CONTINUE READING
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