Biofilms and the plasmid maintenance question.


Can a conjugative plasmid encoding enhanced biofilm forming abilities for its bacterial host facilitate the persistence of the plasmid in a bacterial population despite conferring diminished growth rate and segregative plasmid loss on its bearers? We construct a mathematical model in a chemostat and in a plug flow environment to answer this question. Explicit conditions for an affirmative answer are derived. Numerical simulations support the conclusion.


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@article{Imran2005BiofilmsAT, title={Biofilms and the plasmid maintenance question.}, author={Mudassar Imran and Don A. Jones and Hal L. Smith}, journal={Mathematical biosciences}, year={2005}, volume={193 2}, pages={183-204} }