Biofilm maturity studies indicate sharp debridement opens a time- dependent therapeutic window.

@article{Wolcott2010BiofilmMS,
  title={Biofilm maturity studies indicate sharp debridement opens a time- dependent therapeutic window.},
  author={Randall D. Wolcott and Kendra P. Rumbaugh and George G. James and Greg Schultz and Ppj Phillips and Qingping Yang and Chase Watters and Philip S Stewart and Scot E. Dowd},
  journal={Journal of wound care},
  year={2010},
  volume={19 8},
  pages={
          320-8
        }
}
OBJECTIVE To investigate the hypothesis that newly formed wound biofilms (or bioburdens) are more susceptible to antimicrobial treatment. METHOD Four separate and distinct models were performed by four separate biofilm research laboratories to evaluate the resistance of biofilms to antimicrobial treatments over time. These included a drip-flow biofilm model along with a hydrodebridement study, a porcine skin punch biopsy ex vivo model, a mouse chronic wound model and clinical longitudinal… CONTINUE READING

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