Biofilm formation by Pseudomonas aeruginosa: role of the C4-HSL cell-to-cell signal and inhibition by azithromycin.

@article{FavreBont2003BiofilmFB,
  title={Biofilm formation by Pseudomonas aeruginosa: role of the C4-HSL cell-to-cell signal and inhibition by azithromycin.},
  author={Sabine Favre-Bont{\'e} and Thilo K{\"o}hler and Christian van Delden},
  journal={The Journal of antimicrobial chemotherapy},
  year={2003},
  volume={52 4},
  pages={598-604}
}
OBJECTIVES In Pseudomonas aeruginosa, biofilm formation is controlled by a cell-to-cell signalling circuit relying on the secretion of 3-oxo-C12-HSL and C4-HSL. Previous studies suggested that C4-HSL plays no significant role in biofilm formation. However the wild-type PAO1 strain PAO-BI, used as a control in these studies is itself impaired in the… CONTINUE READING