Biofilm eradication kinetics of the ultrashort lipopeptide C12 -OOWW-NH2 utilizing a modified MBEC Assay(™).

@article{Laverty2015BiofilmEK,
  title={Biofilm eradication kinetics of the ultrashort lipopeptide C12 -OOWW-NH2 utilizing a modified MBEC Assay(™).},
  author={Garry Laverty and Sean P. Gorman and Brendan F. Gilmore},
  journal={Chemical biology & drug design},
  year={2015},
  volume={85 5},
  pages={645-52}
}
In this study, we report the antimicrobial planktonic and biofilm kill kinetics of ultrashort cationic lipopeptides previously demonstrated by our group to have a minimum biofilm eradication concentration (MBEC) in the microgram per mL (μg/mL) range against clinically relevant biofilm-forming micro-organisms. We compare the rate of kill for the most potent of these lipopeptides, dodecanoic (lauric) acid-conjugated C12 -Orn-Orn-Trp-Trp-NH2 against the tetrapeptide amide H-Orn-Orn-Trp-Trp-NH2… CONTINUE READING

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