Biofilm Formation by Staphylococcus Aureus and Pseudomonas Aeruginosa is Associated with an Unfavorable Evolution after Surgery for Chronic Sinusitis and Nasal Polyposis

  title={Biofilm Formation by Staphylococcus Aureus and Pseudomonas Aeruginosa is Associated with an Unfavorable Evolution after Surgery for Chronic Sinusitis and Nasal Polyposis},
  author={Zohra Bendouah and Jean Yves Barbeau and Walid Abou Hamad and Martin Desrosiers},
  journal={Otolaryngology–Head and Neck Surgery},
  pages={991 - 996}

Figures and Tables from this paper

Effectiveness of Topical Antibiotics on Staphylococcus Aureus Biofilm in Vitro

In vitro results show that increased concentrations of antibiotics, easily attainable in topical solutions, are effective in killing bacteria in bacterial biofilms, suggesting a role for topical antibiotic therapies in the treatment of biofilm infections.

Efficacy of a Marine Bacterial Nuclease against Biofilm Forming Microorganisms Isolated from Chronic Rhinosinusitis

The data demonstrate that bacteria associated with CRS form robust biofilms which can be reduced by treatment with matrix-degrading enzymes such as NucB, and may offer an additional therapeutic target for CRS sufferers.

Effectiveness of honey on Staphylococcus aureus and Pseudomonas aeruginosa biofilms

Prevalence of Biofilm-forming Bacteria in Chronic Rhinosinusitis

A high percentage of CRS patients whose sinonasal mucopurulence has biofilm-forming capacity is shown, a possible reflection of the severe nature of their disease.

Activity of Bacteriophages in Removing Biofilms of Pseudomonas aeruginosa Isolates from Chronic Rhinosinusitis Patients

A single dose of phages is able to significantly reduce biofilms formed in vitro by a range of P. aeruginosa biofilm infections and multidrug resistant bacteria.

Characterization of Bacterial and Fungal Biofilms in Chronic Rhinosinusitis

A fluorescence in situ hybridization (FISH) protocol for characterization of bacterial and fungal biofilms in chronic rhinosinusitis (CRS) has validated mucosal tissue cryopreservation for delayed biofilm analysis and highlighted the importance of S. aureus biofilm in the polymicrobial etiology of CRS.

Bacterial Coinfection and Antimicrobial Resistance in Patients with Paranasal Sinus Fungus Balls

Bacterial coinfections were identified in more than two thirds of patients with fungus balls and purulent secretions, suggesting that bacterial infection may influence the development and persistence of clinical symptoms in a substantial portion of fungus ball cases.

Inhibition of Staphylococcus aureus and Pseudomonas aeruginosa biofilms by quatsomes in low concentrations

This is the first study that showed the significant inhibition effect of CPC-quatsomes at low concentrations on both S. aureus and P. aeruginosa biofilms in vitro, and no adverse effects towards cultured human airway epithelial (NuLi-1) cells.

Methods for Removing Bacterial Biofilms: In Vitro Study using Clinical Chronic Rhinosinusitis Specimens

Hydrodynamic delivery of a soap-like surfactant and a calcium-ion sequestering agent may disrupt biofilms associated with CRS.

Determination of the biofilm formation capacity of bacterial pathogens associated with otorhinolaryngologic diseases in the Malaysian population

The hypothesis that chronic otorhinolaryngologic diseases may be biofilm related is supported and the use of molecular methods in combination with conventional microbiological culturing has demonstrated an improvement in the detection of bacteria from such specimens in this study.



Endoscopically Guided Cultures in Chronic Sinusitis

Findings from this study further the understanding of chronic sinusitis and may help guide practitioners in the treatment of this disease.

Evaluation of different detection methods of biofilm formation in Staphylococcus aureus

Abstract. The icaADBC gene locus of Staphylococcus aureus and its polysaccharide intercellular adhesin (PIA/PNSG) were recently identified, but biofilm formation has rarely been detected in vitro. In

Evidence of Bacterial Biofilms in Human Chronic Sinusitis

Morphologic structures that confirm the presence of bacterial biofilms were identified on the sinus mucosa of patients infected with Pseudomonas aeruginosa, a known biofilm former, which may explain the recalcitrant nature of some forms of chronic sinusitis.

Antibiotic susceptibility assay for Staphylococcus aureus in biofilms developed in vitro.

Transmission electron microscopy revealed that cells at the inner biofilm layers tend to remain intact after antibiotic treatment and that TSB-grown biofilms favoured a uniformity of cell distribution and increased cell density in comparison with milk-grownBiofilm aged revealed a reduced matrix distribution and enhanced cell density were observed as the biofilm aged.

The role of biofilms in otolaryngologic infections

Now that basic research has demonstrated that the vast majority of bacteria exist in biofilms, the biofilm concept of disease is beginning to spread throughout the clinical world.

Detection of biofilm-forming strains of Staphylococcus epidermidis and S. aureus

Well-established methods, such as the Congo red agar test are still needed in order to confirm the phenotypic expression in the case of possible phase-variant strains, but the complete knowledge of the genetic mechanisms of phenotype modulation could permit the characterization of the isolates just by molecular means in a single step.

Staphylococcus and biofilms

  • F. Götz
  • Biology
    Molecular microbiology
  • 2002
Concepts for the prevention of obstinate polymer‐associated infections include the search for new anti‐infectives active in biofilms and new biocompatible materials that complicate biofilm formation and the development of vaccines.

The microbiology of recurrent rhinosinusitis after endoscopic sinus surgery.

A wide range of bacteria may be present in the infected post-ESS sinus cavity, with a considerable population of gram-negative organisms, including Pseudomonas species.

Use of Nebulized Antibiotics for Acute Infections in Chronic Sinusitis

  • Winston C. VaughanG. Carvalho
  • Medicine
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • 2002
Nebulized therapy was safe and effective in this cohort of patients with chronic sinusitis and previous endoscopic sinus surgery and endoscopy and outcome measure changes showed consistent improvements.