Bioequivalence study of a generic quetiapine in healthy male volunteers.

  title={Bioequivalence study of a generic quetiapine in healthy male volunteers.},
  author={Werawath Mahatthanatrakul and K Rattana and Somchai Sriwiriyajan and Malinee Wongnawa and Wibool Ridtitid},
  journal={International journal of clinical pharmacology and therapeutics},
  volume={46 9},
AIM To study the bioequivalence of a generic quetiapine (Quantia 200, manufactured by the Unison Laboratories Co., Ltd., Bangkok, Thailand) and the innovator product (Seroquel, AstraZeneca, Macclesfield, UK). VOLUNTEERS AND METHODS The study was a randomized, 2-way crossover design with a 2-week washout period in 24 healthy Thai male volunteers. After a single 200 mg oral dosing, serial blood samples were collected at appropriate interval up to 48 h. Plasma quetiapine concentrations were… CONTINUE READING