Bioequivalence of single and multiple doses of venlafaxine extended-release tablets and capsules in the fasted and fed states: four open-label, randomized crossover trials in healthy volunteers.

@article{Wright2009BioequivalenceOS,
  title={Bioequivalence of single and multiple doses of venlafaxine extended-release tablets and capsules in the fasted and fed states: four open-label, randomized crossover trials in healthy volunteers.},
  author={Clinton W Wright and Mark S Aikman and E. Day Werts and Julia L Seabolt and Jean-Marc C Haeusler},
  journal={Clinical therapeutics},
  year={2009},
  volume={31 11},
  pages={2722-34}
}
BACKGROUND Venlafaxine extended-release (ER) tablets use osmotic pressure to deliver venlafaxine hydrochloride at a controlled rate over approximately 24 hours. OBJECTIVE These studies were conducted to evaluate the bioequivalence of venlafaxine ER tablets and capsules based on the US Food and Drug Administration (FDA) definition. METHODS Four pharmacokinetic studies of the capsule (reference) and tablet (test) formulations were conducted in healthy adult volunteers. The first 2 were… CONTINUE READING