Bioequivalence of coenzyme Q10 from over-the-counter supplements

  title={Bioequivalence of coenzyme Q10 from over-the-counter supplements},
  author={M. V. Miles and P. Horn and L. Miles and P. Tang and P. Steele and T. Degrauw},
  journal={Nutrition Research},
  • M. V. Miles, P. Horn, +3 authors T. Degrauw
  • Published 2002
  • Chemistry
  • Nutrition Research
  • Abstract The objective of this study was to compare the relative bioavailability of two new products with solubilized and non-solubilized over-the-counter (OTC) coenzyme Q 10 products. Nine healthy adults were given single 180 mg doses of each coenzyme Q 10 formulation at two week intervals. A commercially-marketed, non-solubilized Q 10 powder formulation (product D) was only minimally absorbed, and was excluded from the analysis of data. ANOVA comparison of maximum plasma concentrations (C max… CONTINUE READING
    73 Citations

    Figures and Tables from this paper

    Comparison of the relative bioavailability of different coenzyme Q10 formulations with a novel solubilizate (Solu™ Q10)
    • 39
    • PDF
    Relative bioavailability comparison of different coenzyme Q10 formulations with a novel delivery system.
    • 36
    • PDF
    Concentration response to the coenzyme Q10 supplement Q-Gel in human volunteers.
    • 12
    Pharmacokinetic Comparison of a Generic Coenzyme Q10 Solubilizate and a Formulation with Soybean Phytosterols
    • 5
    • Highly Influenced
    Relative Bioavailability of Two Forms of a Novel Water-Soluble Coenzyme Q10
    • 43
    • PDF
    Coenzyme Q10 oral bioavailability: effect of formulation type
    • 17
    • Highly Influenced
    • PDF
    Coenzyme Q10: Absorption, tissue uptake, metabolism and pharmacokinetics
    • 346
    • PDF
    Development of nanoparticulate formulation of coenzyme Q10 and comparison of plasma coenzyme Q10 response in a single supplementation with regular coenzyme Q10 using rats
    • 3


    Relative bioavailability of coenzyme Q10 formulations in human subjects.
    • R. K. Chopra, R. Goldman, S. Sinatra, H. Bhagavan
    • Medicine
    • International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
    • 1998
    • 106
    Coenzyme Q10 in the diet--daily intake and relative bioavailability.
    • 96
    HPLC analysis of reduced and oxidized coenzyme Q(10) in human plasma.
    • 158
    • PDF
    Biomedical and clinical aspects of coenzyme Q
    • G. Littarru
    • Biology, Medicine
    • The clinical investigator
    • 2004
    • 163
    Absorption, tolerability, and effects on mitochondrial activity of oral coenzyme Q10 in parkinsonian patients
    • 102
    • Highly Influential
    Effect of oral coenzyme Q10 supplementation on the oxidation resistance of human VLDL+LDL fraction: absorption and antioxidative properties of oil and granule-based preparations.
    • 60
    Cosupplementation with coenzyme Q prevents the prooxidant effect of alpha-tocopherol and increases the resistance of LDL to transition metal-dependent oxidation initiation.
    • 150
    Usefulness of coenzyme Q10 in clinical cardiology: a long-term study.
    • 88