Bioequivalence of Orally Administered Generic, Compounded, and Innovator‐Formulated Itraconazole in Healthy Dogs

@inproceedings{Mawby2014BioequivalenceOO,
  title={Bioequivalence of Orally Administered Generic, Compounded, and Innovator‐Formulated Itraconazole in Healthy Dogs},
  author={D. I. Mawby and J K Whittemore and Seiche C Genger and M. Papich},
  booktitle={Journal of veterinary internal medicine},
  year={2014}
}
BACKGROUND Itraconazole is commonly used to treat systemic fungal infections in dogs, but problems exist with absorption and cost. OBJECTIVE To determine oral bioequivalence of generic and compounded itraconazole compared to original innovator (brand name) itraconazole in healthy dogs. ANIMALS Nine healthy, adult research Beagle dogs. METHODS A randomized, 3-way, 3-period, crossover design with an 8-day washout period. After a 12-hour fast, each dog received 100 mg (average: 10.5 mg/kg… CONTINUE READING
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