Bioengineering heterodimeric cytokines: turning promiscuous proteins into therapeutic agents.

@article{Belladonna2013BioengineeringHC,
  title={Bioengineering heterodimeric cytokines: turning promiscuous proteins into therapeutic agents.},
  author={Maria Laura Belladonna and Ursula Grohmann},
  journal={Biotechnology & genetic engineering reviews},
  year={2013},
  volume={29},
  pages={149-74}
}
The interleukin 12 (IL-12) family comprises a group of heterodimeric cytokines that can cope with a great variety of immune conditions as the microenvironment demands. By sharing cytokine and receptor subunits, IL-12 (comprised of p40/p35 subunits), IL-23 (p40/p19), IL-27 (p28/EBI3), and IL-35 (p35/EBI3) represent, as a whole, a highly versatile system participating in controlling the continuum from inflammation to tolerance. Promiscuity, a peculiar feature of those cytokines, is a powerful and… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

Similar Papers

Loading similar papers…