Bioenergetics and the epigenome: interface between the environment and genes in common diseases.

@article{Wallace2010BioenergeticsAT,
  title={Bioenergetics and the epigenome: interface between the environment and genes in common diseases.},
  author={Douglas C. Wallace},
  journal={Developmental disabilities research reviews},
  year={2010},
  volume={16 2},
  pages={114-9}
}
Extensive efforts have been directed at using genome-wide association studies (GWAS) to identify the genes responsible for common metabolic and degenerative diseases, cancer, and aging, but with limited success. While environmental factors have been evoked to explain this conundrum, the nature of these environmental factors remains unexplained. The availability of and demands for energy constitute one of the most important aspects of the environment. The flow of energy through the cell is… CONTINUE READING
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