Bioelimination of histamine in epithelia of the porcine proximal colon of pigs

@article{Aschenbach2008BioeliminationOH,
  title={Bioelimination of histamine in epithelia of the porcine proximal colon of pigs},
  author={J. R. Aschenbach and K. U. Honscha and V. von Vietinghoff and G. G{\"a}bel},
  journal={Inflammation Research},
  year={2008},
  volume={58},
  pages={269-276}
}
Abstract.Objective:The study aimed to gain insight into how intestinal histamine N-methyltransferase (HMT) and diamine oxidase (DAO) could contribute to bioelimination of histamine.Material and Methods:Mucosal-to-serosal (ms) and serosal-to-mucosal (sm) fluxes of histamine, choline or 5-hydroxytryptamine were measured in isolated colonic epithelia of pigs (Ussing chambers).Results:Radioactively (hist-rad) and HPLC-measured histamine fluxes were higher in sm vs. ms direction at 100 μM histamine… CONTINUE READING

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