This paper report a novel approach for bioimaging with two different micro/nanoelectrode systems; i. e., scanning electrochemical microscopy (SECM) and individually addressable microelectrode array. Hybrid SECM systems with shear-force or ion-conductance feedback distance control were applied to high resolution and simultaneous imaging of topography and electrochemical responses of enzymes and single live cells. The addressable device with many orthogonally-arranged crossing points for addressable detection of electrochemical signals was applied for characterization of biomaterilas. Micro/nanostructured well arrays have incorporated into the addressable device and applied for imaging of gene expression from single cells. A Bio-LSI for rapid, highly-sensitive, comprehensive analysis was also applied to bioimaging.