Bioelectric signalling via potassium channels: a mechanism for craniofacial dysmorphogenesis in KCNJ2-associated Andersen-Tawil Syndrome.

@article{Adams2016BioelectricSV,
  title={Bioelectric signalling via potassium channels: a mechanism for craniofacial dysmorphogenesis in KCNJ2-associated Andersen-Tawil Syndrome.},
  author={Dany Spencer Adams and Sebastien G M Uzel and Jin Akagi and Donald Wlodkowic and Viktoria Andreeva and Pamela C Yelick and Adrian Devitt-Lee and J W Pare and Michael Levin},
  journal={The Journal of physiology},
  year={2016},
  volume={594 12},
  pages={3245-70}
}
KEY POINTS Xenopus laevis craniofacial development is a good system for the study of Andersen-Tawil Syndrome (ATS)-associated craniofacial anomalies (CFAs) because (1) Kcnj2 is expressed in the nascent face; (2) molecular-genetic and biophysical techniques are available for the study of ion-dependent signalling during craniofacial morphogenesis; (3) as in humans, expression of variant Kcnj2 forms in embryos causes a muscle phenotype; and (4) variant forms of Kcnj2 found in human patients, when… CONTINUE READING
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