Bioelectric signaling regulates head and organ size during planarian regeneration.

  title={Bioelectric signaling regulates head and organ size during planarian regeneration.},
  author={Wendy S. Beane and Junji Morokuma and Joan M Lemire and Michael Levin},
  volume={140 2},
A main goal of regenerative medicine is to replace lost or damaged tissues and organs with functional parts of the correct size and shape. But the proliferation of new cells is not sufficient; we will also need to understand how the scale and ultimate form of newly produced tissues are determined. Using the planarian model system, we report that membrane voltage-dependent bioelectric signaling determines both head size and organ scaling during regeneration. RNA interference of the H(+),K… CONTINUE READING
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