Biodiversity of apidaecin-type peptide antibiotics. Prospects of manipulating the antibacterial spectrum and combating acquired resistance.

@article{Casteels1994BiodiversityOA,
  title={Biodiversity of apidaecin-type peptide antibiotics. Prospects of manipulating the antibacterial spectrum and combating acquired resistance.},
  author={Peter Casteels and J Romagnolo and Michael Castle and K Casteels-Josson and Hediye Erdjument-Bromage and Paul Tempst},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 42},
  pages={26107-15}
}
Insects have a unique repertoire of peptide antibiotics but, to date, prospects of clinical applications are not clear. Apidaecin, a small peptide isolated from honeybees, inhibits viability of Gram-negative bacteria; lethal activity is near immediate, independent of a conventional "lytic" mechanism, and involves stereoselective recognition of target molecules. Here we report structural analysis of 14 naturally occurring apidaecin-type peptides and the existence of evolutionarily conserved… CONTINUE READING

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