Biodistribution studies on L-3-[fluorine-18]fluoro-alpha-methyl tyrosine: a potential tumor-detecting agent.

  title={Biodistribution studies on L-3-[fluorine-18]fluoro-alpha-methyl tyrosine: a potential tumor-detecting agent.},
  author={Tomoyuki Inoue and Katsumi Tomiyoshi and T Higuichi and Khalil Ahmed and Muhammad Usman Sarwar and Kazuhiko Aoyagi and Sadao Amano and Saleh Alyafei and Hanwen Zhang and Keigo Endo},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  volume={39 4},
UNLABELLED Iodine-123-alpha-methyl tyrosine has proven to be a promising SPECT agent for imaging amino acid uptake in tumors. We developed L-[3-(18)F]-alpha-methyl tyrosine (FMT) for PET studies. The aim of this study was to investigate its potential use as a tumor-detecting agent by using tumor-bearing mice. METHODS We investigated the biodistribution in normal BALB/C mice and BALB/cA nude mice bearing human rectal cancer cell line (LS180) until 120 min postinjection. FMT tumor uptake at 60… CONTINUE READING
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