Biodistribution of paclitaxel poliglumex (PPX) in lung: Analysis of gender-related alterations in a preclinical model.

@article{Allievi2006BiodistributionOP,
  title={Biodistribution of paclitaxel poliglumex (PPX) in lung: Analysis of gender-related alterations in a preclinical model.},
  author={C. Allievi and I. Strepponi and U. Bastrup and L. Piazzoni and S. Tavazzi and R. Pisano and G. Pezzoni and M. Fornasier and A. Bernareggi and J. Singer},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2006},
  volume={24 18_suppl},
  pages={17003}
}
  • C. Allievi, I. Strepponi, +7 authors J. Singer
  • Published 2006
  • Medicine
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
17003 Background: PPX is a macromolecular drug conjugate that links paclitaxel with poly-L-glutamic acid; the release of paclitaxel is dependent on metabolism by lysosomal proteases, particularly cathepsin B. Cathepsin B is upregulated by estrogen in both reproductive and somatic tissues that express estrogen beta receptors, including normal lung epithelial cells. Cathepsin B mRNA is also increased by estrogen and decreased by anti-estrogens in the 201T NSCLC cell line (P. Hershberger, personal… Expand
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