Biodistribution of murine and chimeric Fab fragments of the monoclonal antibody A7 in human pancreatic cancer.

@article{Otsuji1995BiodistributionOM,
  title={Biodistribution of murine and chimeric Fab fragments of the monoclonal antibody A7 in human pancreatic cancer.},
  author={Eigo Otsuji and Toshiharu Yamaguchi and Nobuki Yamaoka and Tomio Kotani and Masahiro Kato and Ken Taniguchi and K Kiyamura and Takamune Takahashi},
  journal={Pancreas},
  year={1995},
  volume={10 3},
  pages={
          265-73
        }
}
Much recent research has focused on the use of monoclonal antibodies (MAbs) in the immunodetection of solid tumors. Fab fragments of MAbs are more suitable for immunoscintigraphy than intact MAbs. Recently, human-mouse chimeric antibodies have been developed in an effort to reduce human antimouse antibody (HAMA) production by murine MAbs in humans. In this study, 125I-labeled murine and chimeric Fab fragments of the MAb A7 were injected i.v. into nude mice bearing a human pancreatic cancer (HPC… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-2 OF 2 CITATIONS