Biodistribution of liposomes after extradural administration in rodents.

  title={Biodistribution of liposomes after extradural administration in rodents.},
  author={Vincent J. Umbrain and Mokarram Alafandy and Philip D. Bourgeois and J. D'haese and Jean G. Boogaerts and Gerhard Goffinet and Fr{\'e}d{\'e}ric Camu and Franz Jacques Legros},
  journal={British journal of anaesthesia},
  volume={75 3},
We have mapped over 24 h the biodistribution of 99mTc-labelled multilamellar and small unilamellar liposomes in rabbits and rats by scintigraphic imaging after extradural injection. Multilamellar vesicles formed a depot at the site of injection; small unilamellar vesicles spread immediately along the extradural space and entered the systemic compartment 30 min after injection. Well-delineated liver and kidney labellings were seen after 24 h. The use of 3H-cholesterol-labelled small unilamellar… CONTINUE READING


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