Biodistribution of inhaled gold nanoparticles in mice and the influence of surfactant protein D.

@article{Schleh2013BiodistributionOI,
  title={Biodistribution of inhaled gold nanoparticles in mice and the influence of surfactant protein D.},
  author={Carsten Schleh and Uwe Holzwarth and Stephanie Hirn and Alexander Wenk and Federica Simonelli and Martin Sch{\"a}ffler and Winfried Moeller and Neil Gibson and Wolfgang G Kreyling},
  journal={Journal of aerosol medicine and pulmonary drug delivery},
  year={2013},
  volume={26 1},
  pages={24-30}
}
BACKGROUND The pulmonary route is very promising for drug delivery by inhalation. In this regard, nanoparticulate drug delivery systems are discussed, and one very promising nano carrier example is gold nanoparticles (Au NP). Directly after their deposition, inhaled Au NP come into contact with pulmonary surfactant protein D (SP-D). SP-D can agglomerate Au NP in vitro, and this may influence the clearance as well as the systemic translocation in vivo. The aim of the present study was to… CONTINUE READING
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