Biodistribution of indocyanine green-loaded nanoparticles with surface modifications of PEG and folic acid.

@article{Ma2012BiodistributionOI,
  title={Biodistribution of indocyanine green-loaded nanoparticles with surface modifications of PEG and folic acid.},
  author={Ying Jie Ma and Mostafa Sadoqi and Jun Shao},
  journal={International journal of pharmaceutics},
  year={2012},
  volume={436 1-2},
  pages={25-31}
}
PURPOSE To establish the biodistribution profile of the PLGA nanoparticles with dual surface modifications of PEG and folic acid (FA) in mice xenografted with MDA-MB-231 human breast cancer cells with high expression of folate receptor (FR); and to illustrate that the modified nanoparticles can target the loaded indocyanine green (ICG) to the tumor with high FR expression. METHODS ICG-loaded nanoparticles were prepared with PLGA (non-modified nanoparticles, NM-NP) or mPEG-PLGA and FA-PLGA… CONTINUE READING