Biodistribution of fluorescently labeled PAMAM dendrimers in neonatal rabbits: effect of neuroinflammation.

@article{Lesniak2013BiodistributionOF,
  title={Biodistribution of fluorescently labeled PAMAM dendrimers in neonatal rabbits: effect of neuroinflammation.},
  author={Wojciech G. Lesniak and Manoj K Mishra and Amar Prakash Jyoti and Bindu Balakrishnan and Fan Zhang and Elizabeth Nance and Roberto Romero and Sujatha Kannan and Rangaramanujam M Kannan},
  journal={Molecular pharmaceutics},
  year={2013},
  volume={10 12},
  pages={4560-71}
}
Dendrimers are being explored in many preclinical studies as drug, gene, and imaging agent delivery systems. Understanding their detailed organ, tissue, cellular uptake, and retention can provide valuable insights into their effectiveness as delivery vehicles and the associated toxicity. This work explores a fluorescence-quantification based assay that enables simultaneous quantitative biodistribution and imaging of dendrimers with a single agent. We have labeled an ethylenediamine-core… CONTINUE READING

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