Biodistribution of adeno-associated virus type-2 in nonhuman primates after convection-enhanced delivery to brain.

@article{Cunningham2008BiodistributionOA,
  title={Biodistribution of adeno-associated virus type-2 in nonhuman primates after convection-enhanced delivery to brain.},
  author={Janet Pagan Peter Higgs Stuart Cunningham and Philip J Pivirotto and John R. Bringas and Brian M. Suzuki and Sharmila Vijay and Laura M Sanftner and Marina Y Kitamura and Curtis M. Chan and Krystof S. Bankiewicz},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2008},
  volume={16 7},
  pages={1267-75}
}
A combination treatment of AAV2-hAADC with oral levodopa is a novel therapeutic approach that is being developed for late-stage Parkinson's disease. Biodistribution of AAV2-hAADC was assessed over a wide range of vector dose in 12 monkeys with parkinsonian syndrome, 6 months after intraputamenal infusion. Quantitative PCR (Q-PCR) from all the major neuroanatomical regions of the brain indicated a dose-dependent increase in vector DNA, with 99% being detected in the target site and other basal… CONTINUE READING
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