Biodistribution of PEG-modified gold nanoparticles following intratracheal instillation and intravenous injection.

@article{Lipka2010BiodistributionOP,
  title={Biodistribution of PEG-modified gold nanoparticles following intratracheal instillation and intravenous injection.},
  author={Jens Lipka and Manuela Semmler-Behnke and Ralph A Sperling and Alexander Wenk and Shinji Takenaka and Carsten Schleh and Thomas R. Kissel and Wolfgang J. Parak and Wolfgang G Kreyling},
  journal={Biomaterials},
  year={2010},
  volume={31 25},
  pages={6574-81}
}
Besides toxicity tests, biokinetic studies are a fundamental part of investigations to evaluate a safe and sustainable use of nanoparticles. Today, gold nanoparticles (Au NPs) are known to be a versatile tool in different areas such as science, engineering or medicine. In this study, we investigated the biokinetics after intravenous and intratracheal applications of poly(ethylene glycol) (PEG) modified Au NPs compared to plain Au NPs. Radioactive-labeled Au NPs of 5 nm inorganic core diameter… CONTINUE READING