Biodistribution and radiodosimetry of a novel myocardial perfusion tracer 123I-CMICE-013 in healthy rats

  title={Biodistribution and radiodosimetry of a novel myocardial perfusion tracer 123I-CMICE-013 in healthy rats},
  author={Yin Duan and Julia Lockwood and Lihui Wei and Chad R. Hunter and Karen Soueidan and Corinne Bensimon and Pasan Chinthana Fernando and R. Glenn Wells and Terrence D. Ruddy},
  journal={EJNMMI Research},
  pages={16 - 16}
Background123I-CMICE-013 is a novel radiotracer previously reported to have promising characteristics for single-photon emission computed tomography (SPECT) myocardial perfusion imaging. We evaluated the biokinetics and radiodosimetry of this rotenone-like 123I-labeled tracer in a microSPECT imaging-based study.Methods37 to 111 MBq of 123I-CMICE-013 was synthesized and administered intravenously to 14 healthy rats. Images were acquired with a microSPECT/CT camera at various time intervals and… 

Flow-Dependent Uptake of 123I-CMICE-013, a Novel SPECT Perfusion Agent, Compared with Standard Tracers

The CMICE-013 images showed good contrast between the heart and surrounding organs, with heart-to-liver and heart- to-lung uptake ratios similar to those of the standard tracers.

Biodistribution and radiation dosimetry of 82Rb at rest and during peak pharmacological stress in patients referred for myocardial perfusion imaging

The current effective dose estimate in CAD patients is four times lower than the values reported previously by the ICRP, and about 35 % lower than previous in vivo studies in young healthy subjects.

PET and SPECT Tracers for Myocardial Perfusion Imaging.

An acceleration in the pace of perfusion radiotracer development is demonstrated due to better understanding of the relevant physiology, better chemistry tools and small animal imaging, and good tracers may translate more efficiently from bench to bedside.



New Approach to Quantification of Molecularly Targeted Radiotracer Uptake from Hybrid Cardiac SPECT/CT: Methodology and Validation

The quantitative SPECT/CT approach developed provides a reasonable and reproducible in vivo estimation of absolute radiotracer uptake in the myocardium in a model of myocardial injury and should permit quantitative serial monitoring of subtle changes in theMyocardial uptake of targeted Radiotracers.

Radiation Dose Estimates for [18F]5-Fluorouracil Derived from PET-Based and Tissue-Based Methods in Rats

Normal-tissue absorbed dose estimates for the 18F-labeled chemotherapy agent [18F]5-fluorouracil were derived by PET imaging- and by tissue harvesting-based methods in rats, finding that tissues calculated to receive highest radiation dose by both methods were related to routes of excretion.

The dosimetry of iodine-123 labelled 2β-carbomethoxy-3β-(4-iodophenyl)tropane

This report documents the radiation dosimetry of iodine-123 labelled 2β-carbomethoxy-3β-(4-iodophenyl)tropane [123I]β-CIT in humans. The mean absorbed doses for various organs and the effective dose

Myocardial Uptake of 7′-(Z)-[123I]Iodorotenone During Vasodilator Stress in Dogs With Critical Coronary Stenoses

The ability of 123I-ZIROT to more linearly track blood flow over a wide range makes it a promising new SPECT myocardial perfusion imaging agent with potential for improved coronary artery disease detection and better quantitative estimation of the severity of flow impairment.

Kinetic Modeling, Test–Retest, and Dosimetry of 123I-MNI-420 in Humans

The data indicate that 123I-MNI-420 is a useful SPECT radiotracer for imaging A2A in the brain and has radiation doses that would allow for multiple scans in the same research subject each year.

Small-animal SPECT and SPECT/CT: application in cardiovascular research

This article reviews applications of microSPECT in cardiovascular research in which information about the function and pathology of the myocardium, vessels and neurons is obtained and gives examples on how diagnostic tracers, new therapeutic interventions, pre- and postcardiovascular event prognosis, and functional and pathophysiological heart conditions can be explored by micro SPECT.

Technetium-99m-1,2-bis[bis(2-ethoxyethyl) phosphino]ethane: human biodistribution, dosimetry and safety of a new myocardial perfusion imaging agent.

  • B. HigleyF. Smith A. Lahiri
  • Chemistry, Medicine
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine
  • 1993
Technetium-99m-tetrofosmin can produce high quality myocardial images from 5 min to several hours postinjection, and clearance is excellent from blood, liver, liver and lung.

Radiopharmaceutical Agents for Myocardial Perfusion Imaging

Each RBFM has unique properties that determine the logistics of its use and its test performance characteristics, and it is hoped this detailed overview will assist clinicians in choosing which agent(s) to use and in understanding how to use them.

99 mTc-N-DBODC 5 , a New Myocardial Perfusion Imaging Agent with Rapid Liver Clearance : Comparison with 99 mTc-Sestamibi and 99 mTc-Tetrofosmin in Rats

99mTc-NDBODC5 is a promising new myocardial perfusion tracer with superior biodistribution properties and may shorten the duration of imaging protocols by allowing earlier image acquisition and may markedly reduce the problem of photon scatter from the liver into the inferoapical wall on myocardIAL images.