Biodistribution and radiodosimetry of a novel myocardial perfusion tracer 123I-CMICE-013 in healthy rats

@article{Duan2014BiodistributionAR,
  title={Biodistribution and radiodosimetry of a novel myocardial perfusion tracer 123I-CMICE-013 in healthy rats},
  author={Yin Duan and Julia Lockwood and Lihui Wei and Chad R. Hunter and Karen Soueidan and Corinne Bensimon and Pasan Chinthana Fernando and R. Glenn Wells and Terrence D. Ruddy},
  journal={EJNMMI Research},
  year={2014},
  volume={4},
  pages={16 - 16}
}
Background123I-CMICE-013 is a novel radiotracer previously reported to have promising characteristics for single-photon emission computed tomography (SPECT) myocardial perfusion imaging. We evaluated the biokinetics and radiodosimetry of this rotenone-like 123I-labeled tracer in a microSPECT imaging-based study.Methods37 to 111 MBq of 123I-CMICE-013 was synthesized and administered intravenously to 14 healthy rats. Images were acquired with a microSPECT/CT camera at various time intervals and… 
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Flow-Dependent Uptake of 123I-CMICE-013, a Novel SPECT Perfusion Agent, Compared with Standard Tracers

The CMICE-013 images showed good contrast between the heart and surrounding organs, with heart-to-liver and heart- to-lung uptake ratios similar to those of the standard tracers.

Biodistribution and radiation dosimetry of 82Rb at rest and during peak pharmacological stress in patients referred for myocardial perfusion imaging

The current effective dose estimate in CAD patients is four times lower than the values reported previously by the ICRP, and about 35 % lower than previous in vivo studies in young healthy subjects.

Acute and subacute toxicity studies of CMICE-013, a novel iodinated rotenone-based myocardial perfusion tracer, in Sprague Dawley rats and Gottingen minipigs.

PET and SPECT Tracers for Myocardial Perfusion Imaging.

An acceleration in the pace of perfusion radiotracer development is demonstrated due to better understanding of the relevant physiology, better chemistry tools and small animal imaging, and good tracers may translate more efficiently from bench to bedside.

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