Biodistribution and pharmacokinetics of transgenic pig-produced recombinant human factor IX (rhFIX) in rats.

@article{Chang2008BiodistributionAP,
  title={Biodistribution and pharmacokinetics of transgenic pig-produced recombinant human factor IX (rhFIX) in rats.},
  author={Chih-Hsien Chang and Ta-Kai Chou and Chi-Yu Yang and Tsui-Jung Chang and Yu-Hsien Wu and Te-Wei Lee},
  journal={In vivo},
  year={2008},
  volume={22 6},
  pages={
          693-7
        }
}
BACKGROUND Recombinant human factor IX (rhFIX) is a 56 kDa glycoprotein with full biological activity providing a guarantee of freedom from blood-borne viral contamination in the therapy of hemophilia B, but no data are available on the distribution of transgenic pig-produced rhFIX post injection (p.i.). Therefore, an 131I-radiolabeled rhFIX was developed to evaluate the distribution of rhFIX in rats. MATERIALS AND METHODS rhFIX was labeled with the lodogen method. 131I-rhFIX (25 microCi/25… CONTINUE READING