Biodistribution and metabolism of immunostimulatory oligodeoxynucleotide CPG 7909 in mouse and rat tissues following subcutaneous administration.

@article{Noll2005BiodistributionAM,
  title={Biodistribution and metabolism of immunostimulatory oligodeoxynucleotide CPG 7909 in mouse and rat tissues following subcutaneous administration.},
  author={Bernhard O Noll and Michael J McCluskie and Tanja Sniatala and Angela Lohner and Stephanie Yuill and Arthur M. Krieg and Christian Schetter and Heather L. Davis and Eugen Uhlmann},
  journal={Biochemical pharmacology},
  year={2005},
  volume={69 6},
  pages={981-91}
}
To evaluate pharmacokinetics (PK) and biodistribution, CPG 7909, a 24-mer immunostimulatory fully phosphorothioated oligodeoxynucleotide (PS-ODN), was administered by subcutaneous injection at 2, 5 and 12.5mg/kg to mice and at 9mg/kg to rats. Parent compound and metabolites were isolated from plasma and tissues and quantified by capillary gel… CONTINUE READING