Biodistribution and kinetics of radiolabeled proteins in rats with focal infection.

@article{Oyen1992BiodistributionAK,
  title={Biodistribution and kinetics of radiolabeled proteins in rats with focal infection.},
  author={W. J. G. Oyen and Roel A M J Claessens and Jos W M van der Meer and Frans H. M. Corstens},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={1992},
  volume={33 3},
  pages={388-94}
}
The purpose of this study was to evaluate the role of both protein and radionuclide in the accumulation of 111In-labeled human immunoglobulin G (IgG) in infectious foci. In rats with a calf muscle infection, biodistribution was determined 2, 6, 24, and 48 hr after injection of a radiopharmaceutical. For IgG, human serum albumin (HSA) and human immunoglobulin A (IgA), all labeled with 111In, target-to-background (T/B) ratios were similar throughout the study. However, absolute abscess uptake of… CONTINUE READING

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