Biodistribution and kinetics of holmium-166-chitosan complex (DW-166HC) in rats and mice.

@article{Suzuki1998BiodistributionAK,
  title={Biodistribution and kinetics of holmium-166-chitosan complex (DW-166HC) in rats and mice.},
  author={Yoshio Suzuki and Yuko Momose and Noriko Higashi and Akiyo Shigematsu and Kyong Bae Park and Yeon Kim and Ju Ri Kim and Jei Man Ryu},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={1998},
  volume={39 12},
  pages={
          2161-6
        }
}
UNLABELLED The fate of 166Ho-chitosan complex, a radiopharmaceutical drug for cancer therapy, was determined by studying its absorption, distribution and excretion in rats and mice. METHODS Holmium-166-chitosan complex [0.75 mg of Ho(NO3)3 x 5H2O and 1 mg chitosan/ head] was administered intrahepatically to male rats. Radioactive concentrations in blood, urinary and fecal excretion and radioactive distribution in tissues were examined. To determine the effects of chitosan in 166Ho-chitosan… CONTINUE READING

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