Biodistribution and PET imaging of [(18)F]-fluoroadenosine derivatives.

  title={Biodistribution and PET imaging of [(18)F]-fluoroadenosine derivatives.},
  author={Mian Alauddin and Antranik H Shahinian and Ryan Park and Michael Tohme and John D. Fissekis and Peter Selby Conti},
  journal={Nuclear medicine and biology},
  volume={34 3},
INTRODUCTION Many fluorinated analogues of adenosine nucleoside have been synthesized and studied as potential antitumor and antiviral agents. Earlier, we reported radiosynthesis of 2'-deoxy-2'-[(18)F]fluoro-1-beta-D-arabinofuranosyl-adenine ([(18)F]-FAA) and 3'-deoxy-3'-[(18)F]fluoro-1-beta-d-xylofuranosyl-adenine ([(18)F]FXA). Now, we report their in vivo studies including blood clearance, biodistribution and micro-PET imaging in tumor-bearing nude mice. METHODS Tumors were grown in 6-week… CONTINUE READING