Biodistribution and Clearance of Small Molecule Hapten Chelates for Pretargeted Radioimmunotherapy

@article{Orcutt2010BiodistributionAC,
  title={Biodistribution and Clearance of Small Molecule Hapten Chelates for Pretargeted Radioimmunotherapy},
  author={Kelly Davis Orcutt and Khaled A. Nasr and David G. Whitehead and John V. Frangioni and K Dane Wittrup},
  journal={Molecular Imaging and Biology},
  year={2010},
  volume={13},
  pages={215-221}
}
The favorable pharmacokinetics and clinical safety profile of metal-chelated 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) suggests that it might be an ideal hapten for pretargeted radioimmunotherapy. In an effort to minimize hapten retention in normal tissues and determine the effect of various chemical adducts on in vivo properties, a series of DOTA-based derivatives were evaluated. Biodistribution and whole-body clearance were evaluated for 177Lu-labeled DOTA, DOTA-biotin… CONTINUE READING