Biodistribution, excretion, and toxicity of mesoporous silica nanoparticles after oral administration depend on their shape.

@article{Li2015BiodistributionEA,
  title={Biodistribution, excretion, and toxicity of mesoporous silica nanoparticles after oral administration depend on their shape.},
  author={Linlin Li and Tianlong Liu and Changhui Fu and Longfei Tan and Xianwei Meng and Huiyu Liu},
  journal={Nanomedicine : nanotechnology, biology, and medicine},
  year={2015},
  volume={11 8},
  pages={1915-24}
}
UNLABELLED Mesoporous silica nanoparticles (MSNs) have been proven to be effective drug carriers for oral delivery. However, little attention has been paid to their in vivo biodistribution and toxicity after oral administration. The effect of particle shape on their in vivo behavior is also unknown. In this study, we systematically studied the acute toxicity and biodistribution of three types of MSNs with aspect ratios (ARs) of 1, 1.75 and 5 after oral administration. The effect of particle… CONTINUE READING