Biodesign of a renal-protective peptide based on alternative splicing of B-type natriuretic peptide.

@article{Pan2009BiodesignOA,
  title={Biodesign of a renal-protective peptide based on alternative splicing of B-type natriuretic peptide.},
  author={Shuchong Pan and Hsing Hong Chen and Deborah M. Dickey and Guido Boerrigter and Candace Y. W. Lee and Laurel S. Kleppe and Jennifer Lynn Hall and Amir Lerman and Margaret May Redfield and Lincoln R Potter and Jr. John Burnett and Robert D. Simari},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 27},
  pages={
          11282-7
        }
}
Alternative RNA splicing may provide unique opportunities to identify drug targets and therapeutics. We identified an alternative spliced transcript for B-type natriuretic peptide (BNP) resulting from intronic retention. This transcript is present in failing human hearts and is reduced following mechanical unloading. The intron-retained transcript would generate a unique 34 amino acid (aa) carboxyl terminus while maintaining the remaining structure of native BNP. We generated antisera to this… CONTINUE READING

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Alternative Splicing in CKD.

  • Journal of the American Society of Nephrology : JASN
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Focus on renal congestion in heart failure

  • Clinical kidney journal
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