Biodegradation pattern and tissue integration of native and cross-linked porcine collagen soft tissue augmentation matrices – an experimental study in the rat

  title={Biodegradation pattern and tissue integration of native and cross-linked porcine collagen soft tissue augmentation matrices – an experimental study in the rat},
  author={Daniel Rothamel and M D Benner and Tim Fienitz and Arndt Happe and Matthias Kreppel and Hans-Joachim Nickenig and Joachim E. Z{\"o}ller},
  journal={Head \& Face Medicine},
  pages={10 - 10}
IntroductionWithin the last decades, collagen types I and III have been established as a sufficient biomaterial for GBR and GTR procedures. They might also be an adequate matrix for soft tissue augmentations. However, collagen materials differ significantly regarding resorption time, biodegradation pattern and the invasion of inflammatory cells.The aim of the present study was to compare the biodegradation and tissue integration of native, differently processed and cross-linked collagen… 

In Vitro Biodegradation Pattern of Collagen Matrices for Soft Tissue Augmentation

Fibro-Gide attained the highest resistance to all degradation challenges, and the bacterial collagenase solution was shown to constitute the most aggressive test as all matrices presented 100% degradation before 14 days of storage.

Tissue integration and biodegradation of soft tissue substitutes with and without compression: an experimental study in the rat

Higher levels of compression led to delayed tissue integration and the effect of different compression levels was more distinct when compared to the differences between the materials.

Differential Biodegradation Kinetics of Collagen Membranes for Bone Regeneration

Investigation of the biodegradability of natural collagen membranes found Derma Fina attained the highest resistance to all degradation challenges, while Duo-Teck was the most susceptible membrane to degradation.

In Vivo Comparative Evaluation of Biocompatibility and Biodegradation of Bovine and Porcine Collagen Membranes

Both membranes were considered biocompatible since their tissue reactions were compatible with the physiological inflammatory process; however, the Bio-Gide® was less degraded during the experimental periods, favoring the guided bone regeneration process.

Sequential healing of onlay bone grafts using combining biomaterials with cross‐linked collagen in dogs

Combining biomaterials with cross-linked collagen might contribute to maintaining its initial morphology with excellent biocompatibility in early healing period of lateral onlay grafts.

Impact of Cross-Linking of Collagen Matrices on Tissue Regeneration in a Rabbit Calvarial Bone Defect

In conclusion, the cross-linking of collagen did not influence the potential for bone formation, Nevertheless, Cl_CM might be advantageous for the maintenance of fibrous tissue volume without disturbing bone formation in the defects.

Diverse patterns of bone regeneration in rabbit calvarial defects depending on the type of collagen membrane

UV crosslinking can be a biocompatible alternative to chemical crossl linking and showed distinctive patterns of enhancement in new bone formation in the early phase of degradation and bone regeneration patterns in rabbits.

The Condensation of Collagen Leads to an Extended Standing Time and a Decreased Pro-inflammatory Tissue Response to a Newly Developed Pericardium-based Barrier Membrane for Guided Bone Regeneration

The in vitro and in vivo results revealed that the CPM has a biocompatibility profile comparable to that of the control membrane, making it ideally suited for GBR procedures.

Histomorphometric Comparison between Two Types of Acellular Dermal Matrix Grafts: A Mini Pig Animal Model Study

There was no clear consensus on which graft material was superior but it gave an insight into the tissue response and wound healing process associated with the graft materials.

Collagen Matrix vs. Autogenous Connective Tissue Graft for Soft Tissue Augmentation: A Systematic Review and Meta-Analysis

A systematic review and meta-analysis were conducted to ascertain the efficacy of collagen matrices (CM) compared to autogenous connective tissue graft (CTG) to improve soft tissue dimensions and found that, although autogenous CTG achieves higher values, CM are an effective alternative in terms of total width of KT and MT gain.



Biocompatibility and biodegradation of a native porcine pericardium membrane: results of in vitro and in vivo examinations.

Both examined membranes indicate a high level of biocompatibility and the compact interconnective pericardium collagen of Remotis may have stabilized the resorption process.

Biodegradation of differently cross-linked collagen membranes: an experimental study in the rat.

It was concluded that cross-linking of bovine and porcine-derived collagen types I and III was associated with prolonged biodegradation, decreased tissue integration and vascularization, and in case of TD, BM, BME, VN (2), and VN(3) foreign body reactions.

Biodegradation of three different collagen membranes in the rat calvarium: a comparative study.

The tested membranes differed in their degradation patterns and collagen contents, and should be chosen for each clinical case according to the desired biodegradation characteristics.

Immunohistochemical characterization of guided bone regeneration at a dehiscence-type defect using different barrier membranes: an experimental study in dogs.

It was concluded that angiogenesis plays a crucial role in GBR and all membranes investigated supported bone regeneration on an equivalent level.

Collagen Membrane Resorption in Dogs: A Comparative Study

In the dog, all three tested collagen membranes showed slight to moderate degradation at 1 month and were severely degraded to completely absent at 4 months, suggesting clinicians need to be aware of these resorption rates when selecting membranes for guided tissue and bone regeneration.

Use of a new cross-linked collagen membrane for the treatment of dehiscence-type defects at titanium implants: a prospective, randomized-controlled double-blinded clinical multicenter study.

The results of the present study have indicated that VN supported bone regeneration on a level non-inferior to BG, however, in case of a premature membrane exposure, cross-linking might impair soft-tissue healing or may even cause wound infections.

Properties and modification of porous 3-D collagen/hydroxyapatite composites.

The foreign body reaction to a biodegradable biomaterial differs between rats and mice.

It is concluded that the FBR to HDSC clearly differs between rats and mice, which has consequences for assessment studies on biocompatibility and also on fundamental biomaterial research.

Clinical evaluation of a new collagen matrix (Mucograft prototype) to enhance the width of keratinized tissue in patients with fixed prosthetic restorations: a randomized prospective clinical trial.

These results prove that this new CM was as effective and predictable as the CTG for attaining a band of keratinized tissue, but its use was associated with a significantly lower patient morbidity.

Use of a new cross-linked collagen membrane for the treatment of peri-implant dehiscence defects: a randomised controlled double-blinded clinical trial.

In the present study, the VN membranes with prolonged resorption time demonstrated significantly more adverse events and insufficient bone regeneration compared to the native BG membranes and no advantages in favour of the Vn membranes were detectable.