Biodegradation of differently cross-linked collagen membranes: an experimental study in the rat.

  title={Biodegradation of differently cross-linked collagen membranes: an experimental study in the rat.},
  author={Daniel Rothamel and Frank Schwarz and Martin Sager and Monika Herten and Anton Sculean and J{\"u}rgen Becker},
  journal={Clinical oral implants research},
  volume={16 3},
The aim of the present study was to compare the biodegradation of differently cross-linked collagen membranes in rats. [] Key Method Specimens were randomly allocated in unconnected subcutaneous pouches separated surgically on the back of 40 wistar rats, which were divided into five groups (2, 4, 8, 16, and 24 weeks), including eight animals each. After 2, 4, 8, 16, and 24 weeks of healing, the rats were sacrificed and explanted specimens were prepared for histologic and histometric analysis.

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